Jacek Koziorowski, Ph.D.

Jacek Koziorowski, Ph.D.

Chief Radiochemist, Radiofysikavd, Universitetssjukhuset, Linköping, Sweden

  • Biography
  • Research Interests
  • Publications


Jacek Koziorowski has been working in the field of radiochemistry and radiopharmacy for the last 25 years. His expertise and experience range from the nuclear reactor and accelerator-produced radionuclides over radionuclide separation and radiochemical synthesis to quality control and release of radiopharmaceuticals for human use. His main work is in the field of positron emission tomography (PET) where he is involved in making PET an easier and more achievable tool in developing countries and in translational research to bring PET from bench to bedside. He is currently a board member of the European Association of Nuclear Medicine and Molecular Imaging’s (EANM) Radiopharmacy Committee.

Radiochemistry; Radiopharmacy; Positron Emission Tomography (PET); Molecular Imaging; Oncology; Molecular imaging; Radioimmunotherapy; Translational research; GMP and cGMP; Radionuclide separation; Radionuclide production; Targetry; Accelerators; Cyclotrons; Nuclear reactors


Guidance on current good radiopharmacy practice for the small-scale preparation of radiopharmaceuticals using automated modules: a European perspective, Journal of Labelled Compounds and Radiopharmaceuticals, Published online 08 September 2014, Aerts, J. R. Ballinger, M. Behe, C. Decristoforo, P.H. Elsinga, A. Faivre-Chauvet, T.L. Mindt, P. Kolenc Peitl, S.C. Todde, J. Koziorowski.

EANM guideline for the preparation of an Investigational Medicinal Product Dossier (IMPD), European Journal of Nuclear Medicine and Molecular Imaging, Published online 01 August 2014, S.Todde, A.D. Windhorst, M. Behe, G. Bormans, C. Decristoforo, A. Faivre-Chauvet, V. Ferrari, A.D. Gee, B. Gulyas, C.Halldin, P. Kolenc Peitl, J. Koziorowski, T.L. Mindt, M.Sollini, J. Vercouillie, J.R. Ballinger, P.H. Elsinga.

Influence on free fatty acids on glucose uptake in  prostate cancer cells, Nuclear Medicine and Biology, 41, pp. 254-258, 2014, Andersen K. F., Divilov V.,Sevak K.,  Koziorowski J., NVK Pillarsetty, Lewis J.

Automated synthesis of [18F]FMISO on IBA Synthera®, Journal of Radioanalytical and Nuclear Chemistry, 299, pp 265-270, 2014, Blom E., Koziorowski J.

Dry distillation of radioiodine from TeO2 targets, Applied Sciences, 3, pp. 675-683, 2013, Fonslet J.and  Koziorowski J.

On 11C chemistry reviews – surveying and filling the gaps, Current Organic Chemistry, 17, pp. 2067-2096, 2013, Review article,  Itsenko O., Goméz-Vallejo V., Llop J. and Koziorowski

Antilipolytic drug boosts glucose metabolism in prostate cancer, Nuclear Medicine and Biology, 40, pp.524-528, 2010, Andersen K. F., Divilov V., Koziorowski J., NVK Pillarsetty, Lewis J.

Radiolabelled Somatostatin Analogues for Use in Molecular Imaging, Somatostatin: Synthesis, Mechanisms-of-Action and Physiological Effect,  ISBN: 978-1-62417-419-3, Ed: Allison Anderson and Taylor McAnulty, Book chapter, 2012,  Blom E. and Koziorowski J.

68Ga-Autoclabeling of DOTA-TATE and DOTA-NOC, Applied radiation and isotopes, 70, pp. 980-983, 2012, Blom E., Koziorowski.

Specific activity of 11C-labelled compounds: a big challenge for PET chemists, Positron Emission Tomography, ISBN 978-953-307-824-3 Ed. Chia-Hung Hsieh, Book chapter, 2012,  Gómez- Vallejo V., Gaja V., Koziorowski J., and Llop J.

A quartz-lined carbon-11 target: striving for increased yield and specific activity, Nuclear Medicine and Biology, 37, pp. 343-349, 2010, Koziorowski J., Larsen P., Gillings N.

A simple method for the quality control of [18F]FDG, Applied radiation and isotopes, 68, pp. 1740-1742, 2010, Koziorowski J.

In vivo 19F Magnetic Resonance Spectroscopy and Chemical Shift Imaging of Tri-Fluoro-Nitroimidazole as a Potential Hypoxia Reporter in Solid Tumors. Clinical Cancer research, 13(12), pp. 3738 – 3747, 2007, Procissi D., Claus F., Burgman P., Koziorowski J., Chapman J. D., Thakur S. B., Matei C., Ling C. C., and Koutcher J. A.

Validation of PET hypoxia tracers by autoradiography and fluorescent microscopy, Medical Physics, 32(6), pp. 2055 – 2055, 2005, Pugachev A., Claus F., Sun X., Ruan S., Cai S., Koziorowsky J., Finn R., O’Donoghue J., Ling C. and Humm J.

Direct astatination of a tumour-binding protein, human Epidermal Growth Factor, using nido-carborane as a prosthetic group. Journal of Radioanalytical and Nuclear Chemistry. 256, pp. 191 – 197, 2003. Sjöström A., Tolmachev V., Lebeda O., Koziorowski J., Carlsson J. and Lundquist H.

Iodination of Annexin-V for imaging apoptosis. Journal of Nuclear Medicine, 43, pp.671 – 677, 2002. J. Russell, J O’Donoghue R. Finn,, J. Koziorowski,S. Ruan,  J. Humm and C. C. Ling.

PET imaging of 86Y-labeled anti-lewis y antibodies in a nude mouse model; Comparison between 86Y and 111In radiolabels. Journal of Nuclear Medicine, 42, pp. 1281- 1287, 2001. A. Lövqvist, J. L. Humm, A. Sheikh, R. Finn, J. Koziorowski,  S. Ruan, K. Pentlow, A. Jungbluth, S. Welt, F-T Lee, M. W. Brechbiel and S. M. Larson.

Combined radionuclide- and photodynamic therapy: The activation of photosensitizers by Cerenkov radiation. Journal of Nuclear Medicine, Abstract and oral presentation at SNM 2000.J. Koziorowski, A. M. Ballangrud, M. R. McDevitt, W.-H. Yang, G. Sgouros, J. A. Balatoni and  R. D. Finn.

Low energy cyclotron production and chemical separation of “no carrier added” iodine-124 from a reusable, enriched tellurium-124 dioxide / aluminum oxide solid solution target. Radiochim. Acta. 88 (3-4), pp. 169-173, 2000. Y. Sheh, J. Koziorowski, J. Balatoni, C. Lom, J. R. Dahl and R. D. Finn.

Direct astatination of a peptide, human epidermal growth factor, using nido-carborane as a prosthetic group. Nucl. Med. Commun., 21:594, 2000. Sjostrom A, Tolmachev V, Koziorowski J, Lebeda o,Einarsson L, et al.

Imaging brain tumor proliferative activity with [124I]iododeoxyuridine. Cancer Res., 60, pp. 624-635, 2000. R. G. Blasberg, U. Roelcke, R. Weinreich, B. Beattie, K. von Ammon, Y. Yonekawa, H. Landolt, I. Guenther, N. E. A. Crompton, P. Vontobel, J. Missimer, R. P. Maguire, J. Koziorowski, E. J. Knust, R. D. Finn and K. L. Leenders.

High yield direct 76Br-bromination        of monoclonal antibodies using Chloramine-T. Nucl. Med. Biol., 26, pp. 923 – 929, 1999. Sundin j., Tolmachev V., Koziorowski J., Carlsson J., Lundqvist H., Welt S., Larson S. and Sundin A.

Preliminary results on the production of  66Ga, a non-conventional positron emitter. Proceedings of the 8th workshop on targetry and target chemistry, Eds T. McCarthy and M. Welch, 1999. J. Koziorowski, R. D. Finn, K. S. Pentlow, A. Lövqvist, Y. Sheh, M.

A Cryotrap as Flow Reactor for synthesis of 211At Labelled Compounds. Appl. Radiat. Isot., 50, pp. 527 – 529, 1999. J.Koziorowski, O. Lebeda and R. Weinreich.

Closo-dodecarborate(2-) as a linker for iodination of macromolecules. Aspects on conjugation chemistry and biodistribution. Bioconjugate Chem., 10, pp 338 – 345, 1999. V. Tolmachev, J. Koziorowski, I. Sivaev, H. Lundqvist, J. Carlsson, A. Orlova, L. Gedda, P. Olsson, S. Sjöberg and A. Sundin.

Radiosynthesis and Quality Assurance of 5-[124I]iodo-2´-deoxyuridine for Functional PET Imaging of Cell Proliferation. Nucl. Med. Biol., 25, pp 359 – 365, 1998. I. Guenther, L. Wyer, E. J. Knust, R. D. Finn, J. Koziorowski and R. Weinreich.

A New Convenient Route to Radioiodinated N-succinimidyl 3- and 4-Iodobenzoate, Two Reagents for Radioiodination of Proteins. Appl. Radiat. Isot., 49 (8), pp 955 – 959, 1998. J. Koziorowski, C. Henssen and R. Weinreich.

Simple preparation of 76Br, 123I and 211At labeled 5-halo-2´-deoxyuridine. J. Radioanal. Nucl. Chem., 219(1), pp 127 – 128, 1997. J. Koziorowski and R. Weinreich.

Further evaluation of 6-fluoro-m-tyrosine as a PET tracer for dopamine turnover. Abstr. Pap. Am. Chem. Soc. 208, pp. 53-NUCL, Part 2, 1994. DeJesus O. T., Holden J. E., Endres C. E., Kitchen R., Delacruz L. Murali D., Roberts A. D., Nickles R. J., Shelton L., Freund L., Houser D., Swaminathan S., Sievert M., Koziorowski J. and Ruoho A. E.

Simple automatic quality-control for radiolabeled gases for PET. Appl. Radiat. Isot. 43(8), pp. 1055 – 1056, 1992. M.S. Berridge, E.H. Cassidy and J. Koziorowski.

Structure of  a chiral iridium bis(phosophine)diene complex, a catalyst for homogeneous hydrogenation. Acta Crystallogr. C  47, pp. 437 – 439, Part 2. 1991.  M.S. Abbassioun, P. A. Chaloner, P.B. Hitchcock and J.M. Koziorowski.