Gallium-67 Citrate: A Versatile Diagnostic Agent

Gallium-67 citrate is a radiopharmaceutical compound utilised in nuclear medicine to diagnose and monitor various diseases, particularly inflammation or infection. Gallium-67 (Ga-67) is a radioactive isotope with a half-life of 78.3 hours, allowing it to provide clear images of the body’s structures while minimising radiation exposure to the patient. In addition, gallium-67 citrate, formed by complexing Ga-67 with citrate, is advantageous due to its ability to target specific cells or tissues and its relatively low toxicity. This article will discuss the properties, applications, and limitations of gallium-67 citrate in modern medicine.

Properties of Gallium-67 Citrate

Gallium-67 citrate is administered intravenously to patients and is typically used with single-photon emission computed tomography (SPECT) or gamma camera imaging to produce detailed images of the body’s internal structures. Upon injection, Ga-67 citrate rapidly binds to transferrin, a serum protein responsible for iron transport. The binding to transferrin facilitates the uptake of Ga-67 by cells involved in inflammation or infection, where it accumulates and can be visualised using imaging techniques.

Ga-67 Citrate: A Versatile Tool for Infection, Inflammation, Cancer Diagnosis, and Fever of Unknown Origin

  1. Infection and inflammation: Ga-67 citrate has been proven effective in detecting and localising acute and chronic infections, including abscesses, osteomyelitis, and endocarditis. It can also be used to identify sites of inflammation in conditions such as sarcoidosis and rheumatoid arthritis. In addition, gallium-67 citrate’s ability to accumulate in inflamed or infected tissues allows physicians to identify the source of a patient’s symptoms and monitor treatment progress.
  2. Oncology: In cancer diagnosis, Ga-67 citrate has been used to identify primary tumours, metastatic lesions, and recurrent diseases. Its uptake in tumour cells is related to the increased metabolic activity and blood flow associated with malignancy. Ga-67 citrate has proven useful in detecting lymphomas, lung cancers, and gastrointestinal malignancies.
  3. Fever of unknown origin: Ga-67 citrate can help determine the cause of a fever of unknown origin by localising sites of infection or inflammation that may be driving the fever. This can help physicians develop targeted treatment plans for patients with complex or elusive symptoms.

Limitations and Solutions for Gallium-67 Citrate Imaging: Combining Techniques for Enhanced Diagnostic Accuracy

Due to its versatility, gallium-67 citrate has certain limitations. For example, its sensitivity and specificity can vary depending on the type of infection or cancer being investigated. Additionally, false positives may occur due to non-specific uptake in benign conditions, such as inflammation or recent surgery. To overcome these limitations, Ga-67 citrate imaging is often combined with other diagnostic techniques, such as computed tomography or magnetic resonance imaging, to provide more accurate and detailed information.


Gallium-67 citrate is a valuable diagnostic tool in nuclear medicine, offering a non-invasive means of detecting and localising infection, inflammation, and certain types of cancer. Despite some limitations, its use with other imaging modalities has significantly improved the accuracy of diagnoses and the ability to monitor treatment progress. As advances in nuclear medicine continue, the role of gallium-67 citrate in diagnostics will likely evolve and expand, further benefiting patient care.

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