Rubidium-82 Chloride: A Pivotal Radiopharmaceutical for Myocardial Perfusion Imaging in PET Scan

Rubidium-82 chloride is a widely used radiopharmaceutical in Positron Emission Tomography (PET) imaging, especially for evaluating myocardial perfusion.  The short half-life of Rb-82 (75 seconds) allows for rapid imaging, and its usage can provide crucial insights into cardiac function and coronary artery disease (CAD) diagnosis.

CardioGen-82 is a medical generator that produces rubidium-82 for PET myocardial perfusion imaging.  This radiopharmaceutical generator facilitates a non-invasive imaging method pivotal in diagnosing and managing cardiovascular diseases, especially coronary artery disease.

CardioGen-82: Bridging Timely Diagnosis and Treatment Planning in Cardiac Care through Rapid Rb-82 Generation

CardioGen-82 generates Rb-82 from strontium-82 (Sr-82). Due to the short half-life of Rb-82 (75 seconds), the generator ensures a fresh supply for timely imaging procedures.  Once administered, Rb-82 mimics potassium’s behaviour due to its similar ionic radius, getting absorbed by myocardial cells, thus enabling myocardial perfusion imaging.

Rb-82 is instrumental in diagnosing coronary artery disease, evaluating myocardial perfusion, and evaluating the blood flow through the coronary arteries leading to the heart muscle.  The insights from this imaging help plan revascularisation surgery for patients with known or suspected coronary artery disease.

It provides high-resolution images and enables quantitative analysis, crucial for accurate diagnosis and treatment planning.  The rapid image acquisition due to the short half-life of Rb-82 results in shorter exam times, enhancing patient comfort.

CardioGen-82 has a favourable safety profile.  However, there have been concerns and regulatory advisories regarding potential unintended radiation exposure, and stringent protocols are recommended to ensure safety.  Through CardioGen-82, healthcare professionals can obtain crucial diagnostic information for managing cardiac patients, thus playing a significant role in cardiac imaging.

Ruby-Fill: An Integrated System for Enhanced Cardiac PET Imaging and Safe, Efficient Rubidium-82 Delivery

Ruby-Fill is a closed system utilised to produce rubidium-82 chloride injection for intravenous use, designed explicitly for Cardiac PET imaging to evaluate regional myocardial perfusion in adult patients, particularly those with coronary artery disease problems.  This evaluation is essential as it aids in diagnosing and managing coronary artery diseases.

The Ruby-Fill generator contains accelerator-produced strontium-82, which decays to Rubidium-82. When eluted with saline, a sterile, non-pyrogenic solution of Rb-82 chloride is used for cardiac PET imaging.

The mechanism is similar to CardioGen-82, where Rb-82 mimics potassium due to its similar ionic radius and gets absorbed by myocardial cells, thus aiding in myocardial perfusion imaging.

Ruby-Fill is indicated for use in PET imaging of the myocardium under rest or stress conditions.  The aim is to evaluate regional myocardial perfusion, which is pivotal for adult patients with suspected or existing coronary artery disease.

Ruby-Fill comes with automated safety alerts to help minimise the risk of strontium breakthroughs.  The system lockout feature prevents access to patient infusion controls if quality control is not achieved or strontium levels are elevated.  This ensures that the generated Rb-82 chloride injection is safe for use.

The Ruby-Fill system is engineered for user confidence and efficiency with features like automated quality control and reports, enhanced manoeuvrability, and accurate patient-specific infusion options such as weight-based dosing and constant-activity options.

The Delivery System is due to the short half-life of Rb-82; an elution system is required to deliver Rb-82 chloride into a patient for performing myocardial perfusion imaging with PET.  The Rubidium Elution System has been exclusively designed with the Ruby-Fill Rubidium-82 Generator to provide patients with accurate doses of Rb-82 chloride.

It must be used with an infusion system specifically labelled for use with the generator and capable of accurately measuring and delivering adequate doses of Rubidium Chloride Rb-82 injection​.

Ruby-Fill, like CardioGen-82, plays a crucial role in cardiac PET imaging, providing a reliable and efficient method for evaluating myocardial perfusion, thus aiding in diagnosing and managing coronary artery diseases.


Rubidium-82 chloride PET imaging is a powerful diagnostic tool for assessing myocardial perfusion and aiding in managing coronary artery disease.  Through continuous research and technological advancements, its application is expected to expand, providing even greater insights into cardiac function and potentially other areas of medicine.

The table below summarises the radiopharmaceutical properties of rubidium-82 chloride:

RadioisotopeRubidium-82 (Rb-82)
Half-life75 seconds
Radiation TypePositron emission (β+)
Decay ModeBeta+ decay to stable Krypton-82 (Kr-82)
EnergyThe positron emitted has an energy of about 3.15 MeV
ProductionGenerated from Strontium-82 (Sr-82) in a generator system
Chemical FormRubidium Chloride (RbCl)
Mechanism of ActionMimics potassium due to a similar ionic radius, facilitating myocardial perfusion imaging
AdministrationIntravenous injection
UsageUsed in Positron Emission Tomography (PET) for myocardial perfusion imaging
DistributionPrimarily cardiac uptake due to potassium-mimicking behaviour, minimal distribution elsewhere in the body
EliminationRenal excretion
The table encapsulates key radiopharmaceutical properties of rubidium-82 chloride, a vital agent in cardiac Positron Emission Tomography (PET) imaging. It provides an overview of Rb-82’s radioisotope characteristics, production mechanism from strontium-82, and its administration for myocardial perfusion imaging, emphasizing its short half-life, radiation type, and elimination process. The table succinctly illustrates how Rb-82 chloride properties contribute to its efficacy in diagnosing coronary artery disease, enabling high-resolution imaging and precise evaluation of myocardial blood flow while ensuring patient safety through minimal radiation exposure.

Rubidium-82 chloride properties make it a valuable radiopharmaceutical for cardiac imaging, particularly for evaluating myocardial perfusion and diagnosing coronary artery disease.  The short half-life allows for rapid imaging and minimal radiation exposure to the patient, while the positron emission facilitates high-resolution imaging through PET technology.

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