Journal of Diagnostic Imaging in Therapy
JDIT is published online by Open Medscience, based in Northern Ireland, United Kingdom addressing the needs of researchers who specialise in nuclear medicine and medical imaging sciences by providing open access to peer-reviewed articles.
JDIT publishes clear and concise articles, including thematic issues, on the topics of Nuclear Medicine, Diagnostic Imaging and Therapy. These topics relate to the application of radionuclides, X-rays and ultrasound. Other imaging modalities include hybrids of positron emission tomography (PET), computed tomography (CT) and/or magnetic resonance imaging (MRI).
The aim is to provide a platform for scientific information in the format of research articles, review articles, case reports, communications, letters, commentaries and perspectives.
JDIT Medical Journals
- Following submission, the article will be evaluated for its aims and scope, according to the editorial policy of JDIT.
- The editorial board and/or external experts in their respective fields aim to complete the formal peer-review process within one cycle of 28 days.
- On publication, the article will be assigned a CrossRef DOI number and HTML CrossMark to indicate the current version.
- JDIT is registered in the ROAD (Directory of Open Access Scholarly Resource) database and all articles are archived in the British Library.
- JDIT aims to maximise exposure of the published article throughout its extensive media links, used by Open Medscience.
- JDIT provides an annual editorial review of the published articles, including article alerts.
Synthesis, NMR analysis and applications of isotope-labelled hydantoins | Simon G. Patching | School of BioMedical Sciences and the Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK | Abstract This review concerns methods of synthesis, NMR analysis and applications of isotope-labelled hydantoins. The hydantoin moiety is present in natural products and in extraterrestrial ice, indicating this to be an important compound in prebiotic chemistry. Bacterial transport proteins that scavenge hydantoins have been identified, isolated and characterised with isotope-labelling of hydantoins as an essential requirement to achieve this.
These are Mhp1 from Microbacterium liquefaciens and PucI from Bacillus subtilis, transporting 5-aryl-substituted hydantoins and allantoin, respectively. The hydantoin ring is a useful centre in synthetic chemistry, especially for combinatorial chemistry, multicomponent reactions and in diversity-oriented synthesis. It is also found in pharmacologically active molecules, such as the anticonvulsant phenytoin. Hydantoins synthesised with isotope labels include hydantoin itself, allantoin, other 5-monosubstituted derivatives, phenytoin, other 5,5-di-substituted derivatives, N-substituted derivatives and other more complex molecules with multiple substituents.
Analysis of isotope-containing hydantoins by NMR spectroscopy has been important for confirming purity, labelling integrity, specific activity and molecule conformation. Isotope-labelled hydantoins have been used in a range of biological, biomedical, food and environmental applications including metabolic and in vivo tissue distribution studies, biochemical analysis of transport proteins, identification and tissue distribution of drug binding sites, drug metabolism and pharmacokinetic studies and as an imaging agent.
Call for papers
Positron emission tomography (PET) for functional imaging of human health and disease and drug discovery
This thematic issue in JDIT is concerned with the important and widespread clinical nuclear medicine tool of positron emission tomography (PET) for functional and metabolic in vivo imaging of the human body. Contributions (research articles, review articles, case reports, communications, letters, commentaries and perspectives) are invited in any aspect of PET imaging and some suggestions for topics are given below:
- Generation of positron emitting radionuclides, synthesis and quality control of radiotracers and development of novel radiotracers
- Administration of radiotracers and patient preparation strategies
- Use in assessing human health and in diagnosing and monitoring diseases including cancers and non-malignant tumours, neurological disorders, cardiovascular diseases and underlying conditions and the effects of diabetes and other conditions on PET imaging
- Muscoskeletal imaging (e.g. fluoride-PET)
- Monitoring the effects of drug treatments and use in clinical trials of new drugs and in animal studies (e.g. microPET, RatCAP)
- Assessment of functions and infection of implantable devices and prosthetics
- Roles and characterisation of associated membrane transporters and/or target receptors, characterisation of the underlying metabolism and control pathways and changes in expression and/or activity of associated biological markers
- Metabolism and fate of radiotracers
- Novel molecular and disease targets for PET imaging
- Detector design and PET image construction, developments in mathematical handling and computation of data, improvements in image sensitivity and resolution
- Multidimensional, dynamic and time-resolved PET and coupling of PET with other imaging modalities (e.g. PET-CT, PET-MRI) to produce fused images
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