Exosomes are cell-signalling extracellular vesicles that help calm inflammation, support extracellular matrix (ECM) renewal, guide pigment pathways toward balance, and create a pro-healing environment, outcomes that are particularly important for ageing skin, post-procedure recovery, dyschromia, and hair thinning. CALECIM® Professional uses PTT-6®, an exosome-rich conditioned media, to deliver these signals topically for face and scalp, with in-vitro and clinical data showing ECM upregulation, faster post-laser recovery, and measurable improvements in hair parameters.
How CALECIM® PTT-6® Conditioned Media Targets Regenerative Needs
The frontier of aesthetic regeneration is shifting from cell-based therapies to acellular signalling, utilising highly sophisticated biological messengers known as Extracellular Vesicles (EVs) or exosomes. These nanoscale carriers transport crucial proteins, growth factors, and genetic material, effectively delivering “Youth Messages” that instruct skin and hair cells to rejuvenate and repair at a foundational level.
CALECIM® Professional’s signature ingredient, PTT-6®, is a proprietary conditioned media formulated from stem cells. This secretome harnesses the potency of neonatal stem cell signals, offering a standardised, stable, and highly effective regenerative solution.
Core Benefits and Mechanism of Calecim PTT-6®
- Mechanism of Action: PTT-6® stimulates dermal fibroblasts, enhancing the production of Extracellular Matrix (ECM) components essential for youthful structure and function.
- Skin Restoration Metrics: CellResearchCorp studies confirm a 56% increase in Elastin and an 83% increase in Hyaluronic Acid (HA) production in human dermal fibroblasts, addressing skin laxity and volume loss.
- Scalp Health Metrics: Clinical observations revealed a potent anti-inflammatory action, achieving a 30-fold reduction in inflammatory markers around hair follicles, coupled with a 24% increase in hair follicle cell growth.
- Primary Application: The ideal solution for accelerating post-procedure recovery, such as laser, microneedling, and PRP, as well as promoting long-term reversal of thinning hair and ageing.
A Cellular Comparison: PTT-6® Conditioned Media vs. Traditional Growth Factors
In the regenerative landscape, PTT-6® conditioned media provides a standardised, potent alternative to traditional autologous treatments. By leveraging cell-free technology derived from highly functional stem cells, PTT-6® ensures consistency and maximised regenerative potential.
Regenerative Protocols: How to Use PTT-6® for Skin and Scalp Health
The use of CALECIM® products is intended to take advantage of PTT-6®’s anti-inflammatory and repair signalling exactly when the skin is most vulnerable or receptive to deep treatment.
Step-by-Step for Post-Aesthetic Procedure Recovery
- Immediate Post-Procedure Application: After non-ablative or ablative procedures such as fractional laser, microneedling, or PRP injections, liberally apply CALECIM® Professional serum or cream to the treated area.
- Calm & Repair Mechanistic Rationale: The high concentration of PTT-6® signals the beginning of the natural repair cascade. Clinical trials confirm its capacity to significantly decrease erythema and oedema, with effects starting as early as 3 hours post-laser treatment. This rapid modulation of inflammation reduces the time patients need to recover.
- Ongoing Support: Continue the application twice daily for the first week to sustain signalling. This promotes optimal tissue remodelling by constantly sending the messages required for collagen deposition and efficient re-epithelialization, thereby protecting the aesthetic investment.
Which Skin Concerns Exosomes Target and How CALECIM Can Help
Exosomal signalling targets multiple mechanisms responsible for dermal deterioration, providing a comprehensive approach to skin and hair restoration.
1. Chronological and Photo-Ageing
Ageing is characterised by cellular senescence and the breakdown of the ECM. Exosomes derived from stem cells have the ability to restore physiological function to the skin as well as regenerate or rejuvenate damaged skin tissue via various mechanisms, according to PubMed Central. Exosomes carry specific cargo that suppresses degradation enzymes and stimulates fibroblasts to build new structural components.
- Targeted Outcome: PTT-6® promotes a 56% increase in elastin and an 83% increase in hyaluronic acid production, leading to dermal volume restoration and an average improvement in skin density of 600%.
2. Pigmentary Dysregulation
Chronic inflammation and oxidative stress often trigger or exacerbate hyperpigmentation and uneven skin tone.
- Targeted Outcome: Exosomes contain regulatory factors that help modulate melanocyte activity by downregulating key pigmentation enzymes, and their anti-inflammatory role stabilises the microenvironment, leading to a refined and clearer skin tone.
3. Wound Healing and Scar Remodelling
In tissue repair, exosomes promote the proliferative phase by activating essential cells and fostering a proangiogenic environment. Clinical findings published on MDPI revealed that exosome-based treatments improve wound healing by increasing angiogenesis, reepithelialisation, collagen deposition and reducing scar formation.
- Targeted Outcome: CALECIM® accelerates re-epithelization, enhances fibroblast characteristics, and optimizes the deposition of the ECM, resulting in faster recovery and improved tissue quality following clinical procedures.
4. Hair Thinning and Follicular Health
Inflammation is a primary driver of hair follicle miniaturisation in pattern baldness. PTT-6® addresses the root cause, which is inflammation, as well as the reduced growth effect.
- Targeted Outcome: PTT-6® delivers a 30-fold reduction in inflammation around the follicle and stimulates a 24% increase in hair follicle cell growth, which has been shown in laboratory studies to match the effectiveness of minoxidil. Clinical use over 12 weeks resulted in a 16% increase in hair shaft thickness.
Frequently Asked Questions
Is it safe for melasma or PIH-prone skin?
It is often suitable as part of a dermatologist-directed plan. Pair with daily broad-spectrum SPF and follow your clinician’s advice for hydroquinone/retinoids or device-based care.
Can I use CALECIM® with retinoids, vitamin C, or acids?
Generally, yes. After microneedling/laser, follow a bland skincare window per your provider before re-introducing strong actives.
When should I apply it around procedures?
Follow your clinic’s protocol. Many practices apply CALECIM® immediately or within hours post-treatment to support comfort and visible recovery.
Who should avoid or seek medical advice first?
Anyone with an active infection, open wounds, known sensitivities, or complex dermatoses should consult a clinician. Patch test if you’re reactive.
Can I microneedle at home with it?
Yes, use short needles of less than 0.5 mm for product absorption, disinfect tools thoroughly, and limit frequency. Deeper needling belongs in a clinic.
Disclaimer
This article is provided for informational and educational purposes only and does not constitute medical advice, diagnosis, or treatment. The products, technologies, and scientific findings discussed should not be interpreted as guarantees of results, and individual responses may vary. Always consult a qualified healthcare professional or dermatologist before beginning any new skincare, aesthetic, or scalp treatment, particularly if you have existing medical conditions, active skin concerns, or are undergoing clinical procedures. CALECIM® products are not intended to replace professional medical care, and no claims are made regarding the prevention, treatment, or cure of any disease. The information presented here should not be used as a substitute for personalised clinical guidance.
