If you make high-precision products, think semiconductors, biotech, pharma, or advanced medical devices, a cleanroom isn’t optional. It’s a core part of your process. These controlled environments safeguard your production line so your products don’t fall short of strict quality standards.
Now, if you’re planning to upgrade or switch in 2026, how do you choose the right company? The market isn’t exactly small. Estimates put the global cleanroom market at around $8.3 billion in 2023, with projections pushing it toward $12.3 billion by 2029. That’s a lot of vendors, a lot of promises, and a lot of room to make the wrong call.
In this piece, we’ll be looking at six modular cleanroom manufacturers that have been topping the list recently, so you can narrow your options and find a partner that actually fits your needs.
Top Modular Cleanroom Solutions
Now, let’s look at six of the top players in the modular cleanroom manufacturing niches.
1. American Cleanroom Systems
American Cleanroom Systems (ACS) has been in the business of modular cleanroom design since 1976. This translates into nearly 50 years of cleanroom manufacturing for a wide range of applications, including pharma, medical devices, biotech, aerospace, and advanced industries.
ACS doesn’t just build, it handles the full process, from early design drawings to final installation, which removes a lot of friction for regulated teams.
One of their standout features is their 48-hour quote turnaround, which is possibly the fastest in the clean rooms industry. They also have a really fast process, with some projects moving from order to install in about six weeks.
Why Choose ACS
- Over 50 years of cleanroom experience
- True turnkey design, build, and install
- In-house manufacturing for better quality control
- Strong ISO and cGMP compliance track record
- Trusted by major brands and U.S. national labs
2. PortaFab Corporation
PortaFab is a long-standing player in modular building systems, and they bring that experience straight into cleanroom design.
Founded in the early 1980s and based in Missouri, they design and manufacture prefabricated cleanrooms, in-plant offices, and industrial partitions.
Their CleanLine and FabLine cleanroom systems cover ISO Class 4 to 8, and come in standard sizes that ship fast, which helps when timelines are tight.
PortaFab focuses on strong engineering and well-built panels, not full turnkey installs. So if you already have a general contractor or architect in place, they tend to fit neatly into the project without friction.
Why Choose PortaFab
- Proven modular cleanroom systems with flexible layouts
- Fast lead times through standard quick-ship sizes
- Strong in-house engineering support
- Good fit for GC or architect-led projects
- Broad experience beyond cleanrooms, including offices and partitions
3. Plascore Inc
Plascore is another big name in the cleanroom niche and specialises in engineered honeycomb core, composite panels, and modular cleanroom systems for pharmaceutical, biotech, medical device, and electronics environments.
Their honeycomb panel construction is lightweight, rigid, easy to keep clean, and ideal for regulated spaces.
Plascore isn’t just cleanrooms, though. The company also engineers honeycomb solutions for aerospace, automotive, marine, and defence applications.
Why Choose Plascore
- Proven honeycomb panel technology
- True modular and nonprogressive wall systems
- Designed for pharma-grade cleanability
- Easy future expansion or reconfiguration
- Strong in-house engineering and testing
4. Modular Cleanrooms, Inc
Modular Cleanrooms, Inc. has over 40 years of hands-on experience delivering hardwall and softwall cleanrooms that meet strict air quality and compliance needs across pharma, aerospace, medical devices, and advanced manufacturing.
The most interesting thing about this company is its practical approach. They help you think through layout, budget, and future expansion before anything is built. What’s more? You’ll actually know that you’re working with people who have solved these problems many times before.
Why Choose Modular Cleanrooms
- Decades of real-world cleanroom experience
- Custom hardwall and softwall solutions
- Full turnkey design and installation
- Works across regulated and industrial sectors
- Flexible systems that can scale or reconfigure over time
5. G-CON Clean Solutions
G-CON Clean Solutions (GCS) is a division of G-CON Manufacturing. GCS was formed after the 2022 acquisition of Panelco/ Plasteurop and has since been rebranded to GCS Controlled Environment Experts.
G-CON specialises in high-performance cleanroom infrastructures for the pharmaceutical, biotech, and semiconductor industries. In the cleanrooms niche, G-CON’s particular area of specialisation is POD cleanrooms. These are prebuilt, scalable, and mobile units that can be repurposed as needs evolve.
One standout feature of this cleanroom manufacturer is its off-site construction model. This approach speeds up deployment, often delivering fully operational cleanrooms for a wide range of applications in as little as six months.
They offer turnkey solutions from design and engineering to installation and commissioning.
Why Choose G-CON
- Rapid deployment with off-site construction
- Scalable, flexible PODular cleanroom units
- Compliant with cGMP and other high standards
- Global presence with US and European facilities
- Turnkey solutions from design to commissioning
- Expertise in advanced therapy and biotech sectors
6. Cleanrooms By United
Cleanrooms By United is a trusted name in modular cleanroom design, having been in operation for over 40 years. They specialise in high-quality, prefab modular systems that meet ISO-5 to ISO-8 classifications.
What stands out mostly is their focus on versatility. Since they handle the engineering, manufacturing, and installation in-house, they can tailor a space to your specific workflow without the usual “third-party” headaches.
Whether you are assembling sensitive medical catheters or housing aerospace components, their UL-certified panel systems are designed and built to grow or move right along with your operations.
Why Choose Cleanrooms By United
- Over 40 years of industry experience
- Flexible, modular design for future expansion
- Custom designs tailored to specific industry needs
- ISO 14644-1 compliant, ensuring regulatory confidence
- Energy-efficient and UL-mark certified systems
How to Compare Modular Cleanroom Manufacturers in 2026
Picking a partner isn’t just about the price tag. Here is how I suggest you filter your options this year.
- Compliance & Certification: First things first. Your cleanroom manufacturer must meet the ISO standards and other regulations specific to your industry. This is absolutely non-negotiable. For pharmaceutical work, that means GMP (Good Manufacturing Practice) and FDA guidelines. Semiconductors may require different classifications but equally strict requirements.
- Build Quality & Materials: It’s important that you know the type of material they use in their setup. If possible, ask for a sample of their wall panel. Feel it. Ask about the core material and the finish. Is it a durable, cleanable cleanroom panel? Make sure it’s right for your field.
- Installation & Scalability: You need a manufacturer who can deliver when promised and scale with you. You can know if they meet this requirement by asking how many projects they have queued. What is their typical lead time? Also, ask for the literal instructions on how to add a panel or move a wall in five years. If it sounds like a PhD-level task, that’s a problem.
- Technology Integration: We are in the era of “Smart Cleanrooms”, and you don’t want to be behind the curve. So, look for vendors that offer real-time environmental monitoring with IoT sensors and analytics. Your systems should let you view particle counts or alerts on mobile devices or dashboards.
- Vendor Support & Service: Finally, be sure to find out what their support looks like. Where are their service techs based? What’s their average response time? And if you know someone already using them, call and ask, “How were they to work with after the check cleared?”
Making Your Final Decision
The global cleanroom construction market is growing at an impressive rate. That growth means more options. But it also means more vendors who might overpromise and underdeliver. But not the companies highlighted in this piece. These ones have track records you can verify.
So, which should you go with?
Your decision should come down to alignment. Which manufacturer understands your industry? Whose technology approach matches your operational philosophy? Who can support you not just through installation but through commissioning, validation, and ongoing operations?
Answer these questions, but don’t rush things. If you can, take the time to visit the facilities they’ve built. Talk to actual users. Get detailed proposals and compare them carefully.
You want a modular cleanroom solutions provider that’s not just a vendor, but also a long-term partner. So, choose intentionally.
Disclaimer
This article, Top 6 Modular Cleanroom Companies & How to Compare Them (A 2026 Guide), is published by Open MedScience for general informational purposes only. It is not professional, engineering, legal, regulatory, financial, procurement, or health and safety advice, and it should not be relied upon as a substitute for consulting qualified professionals who can assess your specific site, process, risk profile, and compliance obligations.
Company names, product names, specifications, lead times, certifications, and capabilities may change without notice. While reasonable care is taken to present information believed to be accurate at the time of publication (2026-02-07), Open MedScience makes no warranties or representations, express or implied, about the completeness, accuracy, reliability, suitability, or availability of the information in this article. Any reliance you place on the content is at your own risk.
References to particular companies are provided for comparative context and do not constitute an endorsement, recommendation, or guarantee of performance. You should conduct your own due diligence before selecting any cleanroom supplier, including (where relevant) validation strategy, ISO 14644 classification requirements, GMP expectations, commissioning and qualification approach (IQ/OQ/PQ), documentation quality, service coverage, warranties, change control, and total cost of ownership.
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