SPECT/CT activity quantification in 99mTc-MAA acquisitions
Calibration of a SPECT-CT scanner for activity quantification in technetium-99m macroaggregates.
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Activity Quantification
Activity quantification in medical imaging refers to the measurement of the amount of a radioactive tracer in a particular organ or tissue. This is an important aspect of nuclear medicine, which involves using radioactive materials to diagnose and treat various medical conditions.
Medical imaging techniques such as single-photon emission computed tomography (SPECT) and positron emission tomography (PET) are used to accurately measure the amount of tracer in the body. PET imaging involves injecting a small amount of a radioactive tracer into the body, which is then detected by a special camera.
The camera captures images of the tracer as it moves through the body and accumulates in different tissues and organs. The images are then used to create a three-dimensional map of the tracer distribution in the body. The amount of tracer can be quantified by measuring the intensity of the tracer signal in a particular area of the body.
SPECT imaging is similar to PET imaging, but instead of detecting positrons emitted by the tracer, it detects gamma rays. SPECT is often used to image organs such as the heart, brain, and liver. Activity quantification is important in nuclear medicine because it allows doctors to accurately diagnose and treat various medical conditions. For example, PET imaging can be used to detect cancerous tumours by measuring the amount of glucose uptake in different areas of the body.
This information is used to determine the cancer stage and guide treatment decisions. Another example of the importance of activity quantification is treating thyroid disorders. Radioactive iodine (RAI) treats hyperthyroidism and thyroid cancer. By measuring the amount of RAI uptake in the thyroid gland, doctors can determine the appropriate dosage of RAI to administer to the patient.
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