Why Carbon-14 Still Rules Radiotracing Science
Uncover the key uses of Carbon-14 radiotracers. Learn how they contribute to environmental science and biochemical studies.
Why Carbon-14 Still Rules Radiotracing Science Read Article »
Radiolabelling is a widely applied technique in chemistry, biology, pharmacology, and environmental science for tracking the behaviour and distribution of specific compounds. It involves the incorporation of a radioactive isotope into a molecule, creating a radiolabelled compound that is chemically identical to its non-radioactive counterpart but can be detected with high sensitivity. By replacing a stable atom in the molecule with its radioactive isotope, researchers can follow the compound’s movement, transformation, and fate in complex systems.
The choice of radionuclide depends on the nature of the study. Common isotopes include tritium (³H), carbon-14 (¹⁴C), phosphorus-32 (³²P), iodine-125 (¹²⁵I), and fluorine-18 (¹⁸F), each offering different decay characteristics, half-lives, and detection methods. Factors such as the compound’s stability, the duration of the investigation, and the required resolution guide isotope selection.
Radiolabelling is achieved through synthetic chemistry or biosynthetic processes, using radionuclide-labelled precursors or reagents in place of non-radioactive equivalents. The label’s position within the molecule is strategically chosen to provide meaningful data—for instance, to monitor degradation, binding, absorption, or metabolic transformation.
Once prepared, radiolabelled compounds can be used in living systems or controlled environments. Detection techniques such as liquid scintillation counting, autoradiography, gamma spectrometry, and positron emission tomography (PET) allow researchers to measure radioactivity at very low concentrations, determine localisation, and track changes over time.
The approach plays a central role in drug development, environmental tracing, biochemical pathway analysis, and material science. In pharmacology, for example, radiolabelling supports ADME (absorption, distribution, metabolism, and excretion) studies by providing precise information about a drug’s fate and metabolite formation. In environmental studies, it enables tracing of pollutants and nutrient cycling.
As radioactive materials are involved, radiolabelling must be carried out under strict safety procedures in licensed facilities, with compliance to regulatory requirements for handling, storage, and waste disposal.
In essence, radiolabelling is a versatile and sensitive tool for investigating dynamic processes at the molecular level, enabling researchers to obtain detailed, quantitative data across a wide range of scientific disciplines.
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