About Open MedScience
By | 5 minutes of readingAbout Open MedScience, we explore nuclear medicine, imaging innovations, AI diagnostics, radiotheranostics, cybersecurity, and radiation therapy advancements.
By | 5 minutes of readingTargeted Radionuclide Therapy
Targeted Radionuclide Therapy (TRT) is an innovative approach to cancer treatment that combines the precision of targeted therapies with the cytotoxic power of radiation. TRT employs radiopharmaceuticals, molecules that selectively bind to tumour cells and deliver radiation directly to the tumour, minimising damage to healthy tissue. As a result, TRT offers improved patient outcomes and fewer side effects compared to conventional cancer treatments. In this article, we will discuss the principles of TRT, its advantages, and potential future developments.
Principles of Targeted Radionuclide Therapy
TRT involves using a vector molecule, such as an antibody, peptide, or small molecule, which binds to specific cancer cell receptors or antigens. This vector molecule is conjugated to a radioactive isotope, such as Lutetium-177 (¹⁷⁷Lu), Yttrium-90 (⁹⁰Y), or Radium-223 (²²³Ra), creating a targeted radiopharmaceutical. Once administered, the radiopharmaceutical circulates throughout the body, binding specifically to cancer cells and delivering targeted radiation to the tumour.
The radiation emitted by the radioactive isotope causes localised ionisation events, resulting in DNA damage, generation of reactive oxygen species, and subsequent cell death. Therefore, the choice of the radioactive isotope depends on the specific properties required for effective treatment, such as the type and energy of radiation emitted, half-life, and chemical compatibility with the vector molecule.
Advantages of Targeted Radionuclide Therapy
There are several advantages of TRT over traditional cancer therapies, such as chemotherapy and external beam radiation therapy:
- TRT allows for the precise delivery of radiation to cancer cells while minimising off-target effects and damage to healthy tissue. This results in fewer side effects and improved patient quality of life during treatment.
- TRT is particularly advantageous for treating metastatic or disseminated disease, as the radiopharmaceutical can reach cancer cells throughout the body.
- TRT can potentially overcome resistance to conventional treatments, as the radiation can destroy cancer cells with radiation-resistant or hypoxic characteristics.
- TRT can be tailored to individual patients based on their specific cancer characteristics, leading to more personalised and effective treatment plans.
Future Developments and Conclusion
Research into TRT is rapidly expanding, with numerous clinical trials investigating its safety and efficacy in various cancer types. As our understanding of TRT improves, advancements in vector molecule design, isotope production, and dosimetry may further enhance this treatment modality’s therapeutic efficacy and safety profile.
Combining TRT with other cancer treatments, such as immunotherapy, targeted therapies, or chemotherapy, could lead to synergistic effects and improved patient outcomes. Additionally, the development of theranostic approaches, which combine diagnostic imaging and therapy in a single radiopharmaceutical, holds great potential for personalised medicine and treatment monitoring.
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By | 5 minutes of reading
Yttrium-90 IsoPet: A Revolutionary Hydrogel for Brachytherapy
By | 9 minutes of readingYttrium-90 IsoPet provides localised cancer treatment by polymerising into a lattice, trapping radioactive microspheres within tumour tissues.
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Yttrium-90 Ibritumomab Tiuxetan (Zevalin): A Landmark in Radioimmunotherapy for Non-Hodgkin’s Lymphoma
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Yttrium-90 Labelled Humanised Anti-Tac for Adult T-Cell Leukaemia and Lymphoma
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Thorium-227 Epratuzumab: A Targeted Alpha Therapy for Relapsed or Refractory CD-22 Positive Non-Hodgkin’s Lymphoma
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Advancing Prostate Cancer Treatment: The Development and Clinical Potential of Lutetium-177 XT033
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RhPSMA: A Dual-Labelling Radiohybrid for Prostate Cancer Diagnosis and Therapy
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Lutetium-177 PSMA-ALB-56: A Promising Radiopharmaceutical for Prostate Cancer Therapy
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Targeting Neurotensin Receptor-1: Lutetium-177 IPN-01087 in Oncology
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Revolutionising Cancer Therapy: Exploring Lutetium-177 FAP-2286, A Theranostic Breakthrough
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mRNA Technology: A Revolution in Medical Science
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Lutetium-177 CTT1403: A Therapeutic Breakthrough in Prostate Cancer Treatment
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Exploring Lutetium-177 AMTG: A Novel Radiolabelled Bombesin Analogue for GRPR-Positive Tumours
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Iodine-131 Weimeisheng: Transforming Advanced Lung Cancer Treatment
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Iodine-131 TM601: Targeting Tumours with Radiolabelled Peptides
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Peptide Receptor Radionuclide Therapy (PRRT): A Breakthrough in Treating Gastroenteropancreatic Neuroendocrine Tumours
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Iodine-131 RPS-001: A Promising Radiolabelled Molecule in Prostate Cancer Therapy
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The Role of Iodine-131 Naxitamab (¹³¹I-3F8) in Treating Neuroblastoma and Other Cancers
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RBE and LET: Advancing Precision in Proton Beam Therapy
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Assessing the Feasibility of FLASH Proton Therapy for Patients with Bone Metastases
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Imaging Techniques Used to Diagnose and Stage Blastoma Tumours
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Radionuclide Therapy Effects Uncovered: The Hidden Impact on Our Organs
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Tritium Radiosynthesis: Illuminating the Pathways of Science and Innovation
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Cancer Radiotheranostics: The Future of Targeted Cancer Therapy
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Radiotheranostic Treatments: A Guide to Types and Their Clinical Applications
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The Role of Alpha Particles in Radiotheranostics
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Terbium Radionuclides for Theranostic Applications in Nuclear Medicine
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Advances in Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumours
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The Fascinating World of Auger Electrons: From Discovery to Modern Applications
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Alpha Particles: Their Properties, Sources, Interactions, and Applications
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Precision in Treatment: The Role of Dosimetry in Radionuclide Therapy
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The Role of Targeted Alpha Radionuclide Therapy in Modern Oncology
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Q&A: Medical Imaging Modalities and Therapy
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Breakthrough in Adrenal Cancer Diagnosis and Treatment: The Rise of Iodine-131 IMAZA and Iodine-123 IMAZA
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Iodine-131 ICF01012: A Promising Diagnostic and Therapeutic Agent for Metastasised Melanomas
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Exploring Iodine-131 CAM-H2 for Treating HER2-Expressing Cancers
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Exploring Iodine-131 BA52: A Novel Melanin-Targeted Therapy for Malignant Melanomas
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The Role of Iodine-131 Apamistamab for Acute Myeloid Leukaemia
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Celebrating World Theranostics Day Honoring Saul Hertz
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Iodine-131 Monoclonal Antibody 81C6 Targets Glioma Cells
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Holmium-166 Phytate Offers a Promising Treatment Option for Chronic Synovitis
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Holmium-166 Chitosan in Radiopharmaceutical Cancer Treatment
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Unlocking the Potential of Copper-67 SARTATE in Targeted Radiopharmaceutical Therapy
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Copper-67 SARbisPSMA New Frontier in Prostate Cancer Treatment
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Unlocking New Horizons in Glioblastoma Treatment: The Potential of Copper-64 Diasparagine
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Bismuth-213 Lintuzumab: A Promising Treatment for Acute Myeloid Leukaemia
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Precision Cancer Therapy: The Promise of Astatine-211 Parthanatine in High-Risk Neuroblastomas
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The Potential of Astatine-211-MX35-F(ab’)2 in Ovarian Cancer Treatment
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Combining Theranostics and Radiomics: The Emergence of Theragnomics
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Therapeutic Nuclear Medicine for Advanced Cancer Treatment – Opportunities and Challenges
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Neuroblastoma Targeting Agents: An Insight into Diagnostic and Therapeutic Advances Read Article »
Bone-Seeking Agents in the Management of Bone Metastases: A Focus on Technetium-99m and Radium-223
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Astatine-211 BC8-B10: A Promising Radioimmunoconjugate for Leukaemia Treatment
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Astatine-211 Radiotheranostics: A New Era in Cancer Treatment
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Actinium-225 PSMA-617: Revolutionising Prostate Cancer Treatment
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Actinium-225 Lintuzumab: A Breakthrough in Acute Myeloid Leukaemia Treatment
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Actinium-225: The Emerging Star in Targeted Alpha Therapy
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Pioneering Targeted Alpha Therapy: Actinium-225 FPI-2068 and Indium-111 FPI-2107 in Solid Tumours
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Indium-111 Pentetate: Targeted Therapy in Oncology, Infection, and Inflammation
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Inaugural editorial review: nuclear medicine, diagnostic imaging and therapy
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Inaugural editorial review: nuclear medicine, diagnostic imaging and therapy Read Article »