Finding the Best Dermatologist in Austin, TX
By | 6 minutes of readingBest Dermatologist in Austin, TX provides comprehensive skin care, specialising in acne treatment, cosmetic procedures, and skin cancer screenings.
By | 6 minutes of readingCancer
Cancer is a product of cellular changes that cause disease through the uncontrolled growth and division of cells. Over the past 150 years, many hypotheses have been proposed to explain the origin of cancer cells. These include the unregulated proliferation of cancer cells, metastasis and the histological classification of the cancer tissue (benign or malignant tumour).
In 1845, Rudolf Virchow found abnormal increases in white blood cells in some patients, and in 1847 identified the condition as a blood disease called leukämie (leukaemia). In 1857, Virchow was the first to identify chordoma, a tumour developed at the skull’s base. Also, in 1858, he presented that cancer cells are the body’s own cells.
Currently, the most accepted theory of cancer is based on the hysteron proteron of the somatic mutation theory (SMT). In this model, the first event (mutations) occurs after the cell has been transformed from a normal cell to a cancer cell via a process termed carcinogenesis. These mutations have increasingly been perceived as the causal event in the origin of the vast majority of cancers.
Currently, this model is challenged by a growing amount of experimental data and arguments that could either not be explained by the model or contradict this model.
One study of three subtypes of ependymoma (glioma) brain tumours found that one subtype carried an intrachromosomal translocation (a segment breaking off the chromosome and rejoining it at a different location), creating a new tumour-driving gene. The second subtype lacked tumour-driving mutations and had epigenetic modifications compared to the third subtype, which had neither gene mutations nor epigenetic aberrations.
Furthermore, the fact that normal tissues can display massive genetic changes, including changes in cancer-initiating and cancer-driving genes. Over the past few decades, several transfer experiments have demonstrated tumour-suppressing effects on normal cytoplasm. These include mitochondrial transfer, which has the ability to suppress tumour growth. This could be demonstrated – despite the presence of cancerous nuclear genomes – by showing the introduction of non-cancerous mitochondria into highly malignant breast cancer cells. This approach reversed the malignancy and down-regulated several oncogenic pathways, such as invasion and in vivo tumour growth.
Moreover, several non-genotoxic (non-mutagenic) carcinogens, including dichlorobenzene and chloroform, initiate cancer formation. Other oncological theories include oxidative phosphorylation, which results in cellular energy loss and highly impacts cancer formation.
Currently, several imaging modalities are available to clinicians who diagnose, stage and treat human cancer: X-ray (plain film and computed tomography), ultrasound, magnetic resonance imaging, single-photon emission computed tomography, positron emission tomography and optical imaging. Of these, only four (MRI, CT, PET and SPECT) are capable of 3-D detection of cancer anywhere in the human body.
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By | 6 minutes of reading
How Can You Best Support Patients Undergoing Radiation Therapy?
By | 6 minutes of readingRadiation therapy support significantly improves patient well-being, addressing physical symptoms, emotional needs, and enhancing treatment outcomes.
How Can You Best Support Patients Undergoing Radiation Therapy? Read Article »
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Yttrium-90 Tabituximab barzuxetan: A Pioneering Radiolabelled Therapy for Synovial Sarcoma
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Yttrium-90 FAPi-04: A Novel Radiotherapeutic Targeting Fibroblast Activation Protein Read Article »
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Exploring Iodine-131 BA52: A Novel Melanin-Targeted Therapy for Malignant Melanomas Read Article »
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Iodine-131 Monoclonal Antibody 81C6 Targets Glioma Cells
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Erbium-169 Citrate: A Revolution in Small Joint Arthritis Treatment
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Unlocking New Horizons in Glioblastoma Treatment: The Potential of Copper-64 Diasparagine
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Bismuth-213 Lintuzumab: A Promising Treatment for Acute Myeloid Leukaemia
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Precision Cancer Therapy: The Promise of Astatine-211 Parthanatine in High-Risk Neuroblastomas
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Astatine-211 Sodium Astatide: The Next Generation in Thyroid Disease Treatment Read Article »
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Combining Theranostics and Radiomics: The Emergence of Theragnomics Read Article »
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Proton Therapy: The Future Of Precision Cancer Treatment
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Proton Therapy: The Future Of Precision Cancer Treatment Read Article »
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Revolutionising Cancer Care: The Promise and Challenges of Radiotheranostics Read Article »
CAR T-Cell Therapy in Targeted Cancer Treatment
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The Breakthrough Role of Thorium-227 in Theranostic Radiopharmaceuticals Read Article »
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Fibroblast Activation Protein Inhibitors (FAPI): A New Frontier in Cancer Diagnosis and Therapy
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Actinium-225 FPI-2059: Targeted Alpha Therapy in Oncology through NTSR1 Targeting
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Theranostics Bridging Diagnostics and Therapy for Targeted Treatment
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The Transformative Impact of Medical Imaging in Oncology
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Lighting the Way in Healthcare: The Transformative Role of Lasers in Medicine
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Immuno-PET: Cancer Detection and Treatment in Nuclear Medicine
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The Role of Chemical Exchange Saturation Transfer (CEST) in Advanced MRI Diagnostics
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Enhancing Diagnostic Precision: The Transformative Impact of Micro-Ultrasound in Medical Imaging
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Technetium-99m Tilmanocept (Lymphoseek): Enhancing the Precision of Sentinel Lymph Node Biopsy in Oncologic Surgery
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Multifaceted Role of Technetium-99m Sodium Pertechnetate in Diagnostic Imaging Read Article »
Lung Cancer Screening: Low Dose CT and the Potential of Photon Counting CT
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Lung Cancer Screening: Low Dose CT and the Potential of Photon Counting CT Read Article »
Iodine-123 Iobenguane: Diagnosis and Evaluation of Neuroendocrine Tumours
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Iodine-123 Iobenguane: Diagnosis and Evaluation of Neuroendocrine Tumours Read Article »
Machine Learning Transforms Cancer Diagnostics
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Machine Learning Transforms Cancer Diagnostics Read Article »
Nucleoside transporters in PET imaging of proliferating cancer cells using 3ꞌ-deoxy-3ꞌ-[18F]fluoro-L-thymidine
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